Structure and function of glomerular basement membrane.
نویسندگان
چکیده
منابع مشابه
[Structure and function of glomerular basement membrane].
The glomerular basement membrane (GBM) is thin extracellular matrices which separate the visceral epithelium of the glomerulus from the capillary endothelium and serves as a filter for blood molecules. GBMs are composed of type IV collagen, laminin, heparan sulfate proteoglycan, entactin/nidogen, fibronectin and other minor glycoproteins which are not characterized. Recent technological advance...
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The collagenous domain of bovine glomerular basement membrane was excised in soluble form by limited pepsin digestion and characterized. The domain amounts to approximately 25% of the whole membrane by weight. The constituent polypeptides were studied using several electrophoresis systems and amino acid analysis. The electrophoresis systems used were a combination of agarose and polyacrylamide...
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The noncollagenous domain hexamer of collagen IV from bovine glomerular basement membrane was further investigated to determine the types of collagen chain from which subunits M2*b and M3 are derived. M2*b was shown to be a shorter form, containing 9 fewer residues, of M2*a which was previously established as the noncollagenous domain of a third chain, a3, of collagen IV (Saus, J., Wieslander, ...
متن کاملStructure and function of basement membrane.
Progress has been made in identifying and characterizing basement membrane macromolecules, including type IV collagen, laminin, a heparan sulfate proteoglycan and bullous pemphigoid antigen. Basement membrane contains a unique collagen, type IV collagen, which is formed of pro alpha 1(IV) (Mr = 185,000) and pro alpha 2(IV) (Mr = 170,000) chains. As opposed to the fibrillar pattern seen with oth...
متن کاملAnti-glomerular basement membrane antibodies.
Basement membranes form an anatomic barrier that contains connective tissue. They are composed of type IV collagen, laminin and proteoglycans. Anti-basement membrane antibodies bind to the non-collagen site of the α3 chain of type IV collagen. A group of renal diseases, pulmonary diseases and perhaps others affecting different organs have long been associated with the presence of antibodies dir...
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ژورنال
عنوان ژورنال: membrane
سال: 1989
ISSN: 0385-1036,1884-6440
DOI: 10.5360/membrane.14.2